Read our latest technical article on the reannotation and redesign of our self-delivering Accell siRNA.
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The human genome comprises approximately six billion DNA nucleotides distributed across 23 pairs of chromosomes , encoding the biological processes underlying health and disease.
Uncover how functional genomic screening reveals drug mechanisms of action - five key design considerations for effective CRISPR screen experiments.
RT-qPCR analysis is critical to success in knockdown experiments. Learn about how to rapidly troubleshoot your knockdown experiment from the RT-qPCR results.
Arrayed siRNA screens are a powerful tool to look at very precise perturbations in cellular pathways.
3D culturing is a valuable and increasingly popular cell culture technique. This model recapitulates some physiological characteristics of tissues and tumors driven by cell-cell and cell-matrix contacts, circumventing the need for in vivo experiments in some cases.
The presence of off-targets effects can greatly complicate the interpretation of experimental data. Dharmacon™ ON-TARGETplus™ siRNAs and CRISPRmod CRISPRi system are designed to knock down the target gene with minimal off-target effects and are powerful tools for orthogonal validation strategies resulting in highly specific readouts.